Daisuke Tsuji Selected Research

Hexosaminidase B

9/2016	Combined replacement effects of human modified β-hexosaminidase B and GM2 activator protein on GM2 gangliosidoses fibroblasts.
1/2016	Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.
6/2011	Therapeutic potential of intracerebroventricular replacement of modified human β-hexosaminidase B for GM2 gangliosidosis.

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Daisuke Tsuji Research Topics

Disease

15	Sandhoff Disease (Sandhoff's Disease) 01/2016 - 01/2005
9	GM2 Gangliosidoses (GM2 Gangliosidosis) 09/2016 - 08/2006
8	Lysosomal Storage Diseases (Lysosomal Storage Disease) 09/2016 - 03/2005
6	Tay-Sachs Disease 01/2013 - 03/2007
4	Neoplasms (Cancer) 02/2023 - 01/2011
3	Neuroinflammatory Diseases 11/2023 - 01/2013
3	Neuraminidase deficiency with beta-galactosidase deficiency 06/2022 - 11/2009
3	Neurologic Manifestations (Neurological Manifestations) 01/2013 - 04/2011
2	Hepatocellular Carcinoma (Hepatoma) 02/2024 - 07/2023
2	Metabolic Diseases (Metabolic Disease) 11/2022 - 04/2011
2	Inflammation (Inflammations) 06/2022 - 01/2021
2	Multiple Myeloma 10/2015 - 01/2013
2	Costello Syndrome 08/2008 - 08/2006
1	Sphingolipidoses (Sphingolipidosis) 11/2023
1	Edema (Dropsy) 06/2022
1	Neuroblastoma 01/2022
1	Breast Neoplasms (Breast Cancer) 07/2021
1	Sepsis (Septicemia) 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Rupture 01/2021
1	Hypertension (High Blood Pressure) 01/2020
1	Nervous System Diseases (Neurological Disorders) 01/2013
1	Human Influenza (Influenza) 10/2011
1	Disease Progression 10/2011
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2009
1	Glycogen Storage Disease Type II (Pompe's Disease) 05/2008

Drug/Important Bio-Agent (IBA)

12	G(M2) Ganglioside (Ganglioside GM2)IBA 01/2016 - 03/2005
7	beta-N-AcetylhexosaminidasesIBA 08/2010 - 03/2005
5	EnzymesIBA 11/2022 - 05/2008
5	ChemokinesIBA 06/2022 - 03/2005
5	Hexosaminidases (Hexosaminidase)IBA 09/2016 - 01/2011
5	OligosaccharidesIBA 01/2013 - 03/2005
4	Proteins (Proteins, Gene)FDA Link 06/2022 - 03/2007
4	Hexosaminidase A (Hex A)IBA 01/2016 - 01/2011
4	GangliosidesIBA 10/2011 - 03/2007
3	Hexosaminidase BIBA 09/2016 - 06/2011
3	Therapeutic UsesIBA 01/2013 - 08/2006
2	erastinIBA 02/2024 - 07/2023
2	Cathepsin AIBA 06/2022 - 01/2018
2	Neuraminidase (Sialidase)IBA 01/2018 - 10/2011
2	Mannose (D-Mannose)IBA 01/2016 - 04/2011
2	IsoenzymesIBA 01/2013 - 03/2007
2	Monoclonal AntibodiesIBA 01/2013 - 03/2007
2	Polysaccharides (Glycans)IBA 08/2010 - 09/2009
2	AcetylglucosamineIBA 06/2009 - 09/2005
2	Messenger RNA (mRNA)IBA 08/2008 - 08/2006
2	TropoelastinIBA 08/2008 - 08/2006
1	SesquiterpenesIBA 02/2024
1	GlycosphingolipidsIBA 11/2023
1	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2023
1	SNARE Proteins (SNAREs)IBA 01/2022
1	TriterpenesIBA 07/2021
1	FTI 277IBA 01/2021
1	Mitochondrial DNA (mtDNA)IBA 01/2021
1	Farnesyltranstransferase (Farnesyltransferase)IBA 01/2021
1	Indicators and Reagents (Reagents)IBA 01/2020
1	Captopril (Capoten)FDA LinkGeneric 01/2020
1	sialooligosaccharidesIBA 01/2018
1	G(M2) Activator ProteinIBA 09/2016
1	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA 01/2016
1	Uridine Diphosphate (UDP)IBA 01/2016
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2016
1	Peptide Hydrolases (Proteases)FDA Link 01/2016
1	Lactic Acid (Lactate)FDA LinkGeneric 10/2015
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 10/2011
1	Zanamivir (Relenza)FDA Link 10/2011
1	Oseltamivir (Tamiflu)FDA Link 10/2011
1	AutoantibodiesIBA 10/2011
1	CorticosteroneIBA 10/2011
1	Dinoprostone (PGE2)FDA Link 01/2011
1	lysoganglioside G(M2)IBA 01/2011
1	Biomarkers (Surrogate Marker)IBA 01/2011
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2011
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2011
1	Daunorubicin (Cerubidine)FDA LinkGeneric 01/2011
1	Adenosine Triphosphate (ATP)IBA 01/2011
1	Enzyme Precursors (Zymogens)IBA 11/2009
1	CytokinesIBA 08/2008
1	CollagenIBA 08/2008
1	Interleukin-8 (Interleukin 8)IBA 08/2008
1	Interleukin-1beta (Interleukin 1 beta)IBA 08/2008
1	Proteoglycans (Proteoglycan)IBA 08/2008
1	alpha-Glucosidases (Acid Maltase)IBA 05/2008
1	AcidsIBA 05/2008
1	Imino SugarsIBA 05/2008
1	AntibodiesIBA 03/2007
1	GlycoconjugatesIBA 03/2005
1	Chemokine CCL3IBA 03/2005

Therapy/Procedure

5	Enzyme Replacement Therapy 01/2016 - 09/2009
4	Therapeutics 09/2016 - 01/2005